Role of Colonization Resistance of Gastric and Intestinal Mucosa in the Development of Gastrointestinal Bacterial Infections

Chicherin IYu1*, Pogorelsky IP2, Kolodkin AM1, Lundovskikh IA2, Shabalina MR2 and Kolevatykh EP3

1Scientific society «Microbiota», Sergiev Posad, Moscow Region, Russian Federation
2Department of Microbiology, Institute of Biology and Biotechnology, Vyatka State University, Kirov, Russian Federation
3Department of Microbiology and Virology, Kirov State Medical University, Kirov, Russian Federation

*Corresponding Author: Chicherin IYu, Scientific society «Microbiota», Sergiev Posad, Moscow Region, Russian Federation.

Received: July 17, 2021 Published: August 25, 2022


The aim of the article is to analyze the role of colonization resistance of the gastric and intestinal mucosa in the development of bacterial gastrointestinal infections in conventional white mice. We created the experimental models of intestinal yersiniosis, pseudotuberculosis, salmonellosis and escherichiosis in conventional white mice by oral administration of bacterial suspensions containing pathogenic strains of Yersinia enterocolitica KM1407, Yersinia pseudotuberculosis KM07, Salmonella enteritidis KM08, Escherichia coli EG, isolated from patients with manifesting infectious diseases. Bacteriological methods were used to confirm bacterial engraftment and generalization of the infectious process. Pathological changes in the stomach and small intestine of dead animals were evaluated using histological sections of the stomach and small intestine. We measured the concentration of bacteria in the stomach and intestine after their single administration at a dose, required to cause symptomatic disease. Oral administration of the metaprebiotic Stimbifid plus (both preventive and therapeutic) to infected animals completely stopped the infectious process. Our findings indicate high therapeutic potential of metaprebiotic Stimbifid plus and its ability to preserve commensal microbiota and colonization resistance that play an essential role in the prevention of intestinal infections and ensure their termination in the early stage.

Keywords: Intestinal Yersiniosis; Pseudotuberculosis; Salmonellosis; Escherichiosis; Microbiota; Colonization Resistance; Stimbifid Plus;

White Mice